Table 1.
Persisting Effects Questionnaire Ratings at one week after each psilocybin session, and 12 months after Psilocybin Session 1*
| Subscale/Item | Mean (SEM) Session 1 |
Mean (SEM) Session 2 |
Mean (SEM) Session 3 a |
Mean (SEM) 12 months |
|---|---|---|---|---|
| Positive attitudes about life | 49.3 (6.5) | 63.2 (4.2) | 69.7 (6.0) | 63.5 (5.9) |
| Negative attitudes about life | 10.4 (3.2) | 6.3 (1.4) | 5.5 (1.4) | 7.0 (2.8) |
| Positive attitudes about self | 42.2 (6.6) | 57.7 (5.2) | 65.3 (5.8) | 60.5 (5.8) |
| Negative attitudes about self | 10.4 (2.4) | 6.1 (1.3) | 6.1 (1.3) | 8.1 (3.1) |
| Positive mood changes | 34.6 (6.0) | 53.5 (5.8) | 62.0 (8.4) | 53.0 (6.4) |
| Negative mood changes | 14.1 (5.4) | 4.4 (1.9) | 5.4 (4.5) | 7.0 (3.6) |
| Altruistic/positive social effects | 34.9 (7.8) | 56.3 (6.0) | 62.2 (7.1) | 57.6 (6.2) |
| Antisocial/negative social effects | 3.5 (1.7) | 2.8 (1.7) | 3.7 (2.2) | 6.5 (2.6) |
| Positive behavior changes | 52.9 (9.3) | 65.3 (7.9) | 80.0 (4.9) | 64.0 (6.8) |
| Negative behavior changes | 7.1 (5.0) | 0.0 (0.0) | 3.3 (2.3) | 4.0 (4.0) |
| Increased spirituality | 40.0 (7.4) | 55.1 (6.0) | 60.5 (7.1) | 55.2 (6.6) |
| Decreased spirituality | 3.4 (1.3) | 1.2 (0.6) | 1.0 (0.5) | 3.2 (1.6) |
| How personally meaningful was the experience? (score range: 1–8) b | 5.4 (0.5) | 6.3 (0.2) | 6.3 (0.3) | 7.0 (0.2) |
| How spiritually significant was the experience? (score range: 1–6) c | 3.4 (0.4) | 4.2 (0.2) | 4.4 (0.4) | 5.1 (0.3) |
| Did the experience change your sense of well-being or life satisfaction? (score range: −3 to +3) d | 1.4 (0.5) | 2.5 (0.2) | 2.7 (0.3) | 2.1 (0.3) |
Data are mean scores with 1 SEM shown in parentheses (N=15); data on attitudes, mood, altruistic/social effects, and behavior changes are expressed as percentage of maximum possible score; data for the final three questions are raw scores.
For Session 3 scores N=12, as 3 participants declined an optional third psilocybin session.
Rating scale: 1=no more than routine, everyday experiences. 2=similar to meaningful experiences that occur on average once or more a week. 3=similar to meaningful experiences that occur on average once a month. 4=similar to meaningful experiences that occur on average once a year. 5=similar to meaningful experiences that occur on average once every 5 years. 6=among the 10 most meaningful experiences of my life. 7=among the 5 most meaningful experiences of my life. 8=the single most meaningful experience of my life.
Rating scale: 1=not at all. 2=slightly. 3=moderately. 4=very much. 5=among the 5 most spiritually significant experiences of my life. 6=the single most spiritually significant experience of my life.
Rating scale: −3=decreased very much. −2=decreased moderately. −1=decreased slightly. 0=no change. 1=increased slightly. 2=increased moderately. 3=increased very much.