Table A 2.2.
Predictions obtained from BRMA PTDF models (and BRMA PNF for comparison) for all studies in the ‘Oba data’.
| Overall survival, mean (95% CrI) | |||||
|---|---|---|---|---|---|
|
Historical trials
|
|||||
| FFCD-8801 | NSAS-GC | JCOG-9206-1 | JCOG-8801 | SWOG-7804 | |
| Observed | 0.84 (0.62, 1.14) | 0.51 (0.29, 0.90) | 0.60 (0.31, 1.18) | 0.82 (0.54, 1.27) | 0.93 (0.70, 1.24) |
| BRMA PNF | 0.87 (0.60, 1.26) | 0.86 (0.47, 1.57) | 0.87 (0.43, 1.75) | 0.87 (0.54, 1.39) | 0.86 (0.60, 1.24) |
| BRMA PTDF (4 df) | 0.87 (0.59, 1.27) | 0.86 (0.46, 1.60) | 0.87 (0.43, 1.77) | 0.87 (0.53, 1.43) | 0.86 (0.60, 1.25) |
| BRMA PTDF (15 df) | 0.87 (0.60, 1.27) | 0.86 (0.47, 1.58) | 0.87 (0.43, 1.75) | 0.86 (0.54, 1.40) | 0.86 (0.60, 1.23) |
| BRMA PTDF (30 df) | 0.87 (0.60, 1.27) | 0.86 (0.46, 1.58) | 0.87 (0.43, 1.76) | 0.87 (0.54, 1.40) | 0.86 (0.60, 1.23) |
| EORTC-40813 | Tsavaris | ICCG-1/81 | ITMO | GITSG-8174 | |
|
| |||||
| Observed | 0.85 (0.64, 1.14) | 0.55 (0.33, 0.89) | 0.85 (0.64, 1.13) | 0.98 (0.70, 1.37) | 0.74 (0.53, 1.04) |
| BRMA PNF | 0.87 (0.61, 1.25) | 0.86 (0.50, 1.48) | 0.87 (0.61, 1.24) | 0.86 (0.58, 1.28) | 0.87 (0.58, 1.29) |
| BRMA PTDF (4 df) | 0.86 (0.50, 1.25) | 0.87 (0.50, 1.50) | 0.87 (0.60, 1.28) | 0.86 (0.57, 1.29) | 0.86 (0.58, 1.29) |
| BRMA PTDF (15 df) | 0.86 (0.60, 1.24) | 0.86 (0.50, 1.48) | 0.87 (0.61, 1.24) | 0.86 (0.58, 1.28) | 0.87 (0.58, 1.29) |
| BRMA PTDF (30 df) | 0.86 (0.59, 1.24) | 0.86 (0.50, 1.47) | 0.87 (0.61, 1.24) | 0.86 (0.58, 1.28) | 0.86 (0.58, 1.29) |
| NCTTG-794151 | ECCOG-EST3275 | EORTC-40905 | ICCG | ||
|
| |||||
| Observed | 1.02 (0.69, 1.51) | 0.94 (0.68, 1.30) | 0.93 (0.64, 1.37) | 1.05 (0.74, 1.49) | |
| BRMA PNF | 0.86 (0.55, 1.34) | 0.86 (0.58, 1.27) | 0.86 (0.56, 1.33) | 0.87 (0.58, 1.32) | |
| BRMA PTDF (4 df) | 0.86 (0.55, 1.37) | 0.86 (0.58, 1.29) | 0.87 (0.55, 1.37) | 0.87 (0.57, 1.33) | |
| BRMA PTDF (15 df) | 0.86 (0.55, 1.35) | 0.86 (0.58, 1.27) | 0.86 (0.55, 1.34) | 0.87 (0.58, 1.31) | |
| BRMA PTDF (30 df) | 0.86 (0.55, 1.35) | 0.86 (0.58, 1.27) | 0.86 (0.56, 1.34) | 0.87 (0.58, 1.31) | |
|
| |||||
|
Validation trials
|
|||||
| A-cirera | B-CLASSIC | E-GOIM-9602 | F-GOIRC | ||
|
| |||||
| Observed | 0.60 (0.39, 0.93) | 0.72 (0.52, 1.00) | 0.91 (0.69, 1.21) | 0.90 (0.64, 1.26) | |
| BRMA PNF | 0.85 (0.52, 1.39) | 0.77 (0.50, 1.19) | 0.88 (0.62, 1.24) | 0.87 (0.59, 1.29) | |
| BRMA PTDF (4 df) | 0.84 (0.51, 1.38) | 0.74 (0.45, 1.21) | 0.87 (0.61, 1.24) | 0.87 (0.58, 1.30) | |
| BRMA PTDF (15 df) | 0.84 (0.51, 1.37) | 0.76 (0.49, 1.15) | 0.87 (0.62, 1.22) | 0.87 (0.58, 1.30) | |
| BRMA PTDF (30 df) | 0.84 (0.52, 1.37) | 0.76 (0.48, 1.20) | 0.87 (0.63, 1.22) | 0.87 (0.58, 1.29) | |