Table 4.
Predictions obtained from all models for all studies in the ‘Sormani data’.
| Disability progression rate ratio, mean (95% CrI) |
|||||
|---|---|---|---|---|---|
| Paty (1) | Paty (2) | Miligan | Johnson | Jacobs/Simon | |
| Observed | 1.00 (0.67, 1.49) | 0.71 (0.45, 1.12) | 1.14 (0.26, 5.03) | 0.88 (0.57, 1.35) | 0.63 (0.38, 1.05) |
| Meta-regression (FE) | 0.99 (0.66, 1.48) | 0.84 (0.53, 1.33) | 0.93 (0.21, 4.11) | 0.87 (0.56, 1.35) | 0.85 (0.51, 1.42) |
| Meta-regression (RE) | 0.99 (0.64, 1.53) | 0.84 (0.52, 1.35) | 0.92 (0.21, 4.13) | 0.87 (0.54, 1.38) | 0.85 (0.50, 1.45) |
| Daniels & Hughes | 0.99 (0.63, 1.54) | 0.84 (0.51, 1.37) | 0.93 (0.20, 4.31) | 0.87 (0.54, 1.41) | 0.85 (0.50, 1.46) |
| BRMA (Wishart) | 1.00 (0.47, 2.13) | 0.81 (0.39, 1.68) | 0.83 (0.16, 4.29) | 0.81 (0.36, 1.82) | 0.82 (0.36, 1.87) |
| BRMA (PNF) | 0.97 (0.60, 1.57) | 0.83 (0.49, 1.40) | 0.86 (0.19, 3.95) | 0.86 (0.52, 1.42) | 0.83 (0.47, 1.48) |
| |
Fazekas | Millefiorini | Achiron | Li (1) | Li (2) |
| Observed | 0.70 (0.36, 1.35) | 0.19 (0.05, 0.79) | 0.82 (0.19, 3.50) | 0.81 (0.61, 1.08) | 0.73 (0.54, 0.99) |
| Meta-regression (FE) | 0.66 (0.34, 1.29) | 0.61 (0.14, 2.55) | 0.63 (0.15, 2.69) | 0.87 (0.65, 1.17) | 0.86 (0.63, 1.17) |
| Meta-regression (RE) | 0.65 (0.33, 1.30) | 0.60 (0.14, 2.53) | 0.62 (0.14, 2.67) | 0.87 (0.62, 1.21) | 0.85 (0.60, 1.20) |
| Daniels & Hughes | 0.65 (0.32, 1.32) | 0.60 (0.14, 2.60) | 0.62 (0.14, 2.73) | 0.87 (0.62, 1.22) | 0.86 (0.60, 1.23) |
| BRMA (Wishart) | 0.70 (0.28, 1.76) | 0.65 (0.14, 3.16) | 0.64 (0.13, 3.16) | 0.85 (0.43, 1.68) | 0.84 (0.39, 1.79) |
| BRMA (PNF) | 0.67 (0.33, 1.38) | 0.65 (0.15, 2.81) | 0.67 (0.15, 2.97) | 0.86 (0.58, 1.25) | 0.84 (0.57, 1.24) |
|
|
Clanet | Durelli | Baumhackl | Polman | Rudick |
| Observed | 1.00 (0.83, 1.20) | 0.43 (0.24, 0.78) | 1.08 (0.74, 1.57) | 0.59 (0.46, 0.75) | 0.79 (0.65, 0.96) |
| Meta-regression (FE) | 1.08 (0.87, 1.34) | 0.88 (0.48, 1.59)* | 0.94 (0.64, 1.39) | 0.58 (0.43, 0.78) | 0.66 (0.53, 0.83) |
| Meta-regression (RE) | 1.08 (0.82, 1.43) | 0.87 (0.48, 1.61)* | 0.94 (0.62, 1.43) | 0.57 (0.40, 0.80) | 0.66 (0.51, 0.86) |
| Daniels & Hughes | 1.10 (0.84, 1.44) | 0.88 (0.47, 1.64)* | 0.94 (0.60, 1.46) | 0.57 (0.39, 0.82) | 0.66 (0.51, 0.87) |
| BRMA (Wishart) | 1.04 (0.60, 1.79) | 0.84 (0.35, 2.01) | 0.91 (0.42, 1.95) | 0.56 (0.27, 1.15) | 0.69 (0.30, 1.59) |
| BRMA (PNF) | 1.07 (0.77, 1.48) | 0.85 (0.45, 1.61)* | 0.91 (0.58, 1.44) | 0.57 (0.37, 0.88) | 0.67 (0.48, 0.94) |
|
|
Coles (1) | Coles (2) | Mikol | Comi (1) | Comi (2) |
| Observed | 0.35 (0.16, 0.74) | 0.38 (0.19, 0.77) | 1.34 (0.88, 2.06) | 0.69 (0.52, 0.93) | 0.73 (0.55, 0.97) |
| Meta-regression (FE) | 0.58 (0.27, 1.26) | 0.49 (0.24, 1.01) | 1.03 (0.66, 1.60) | 0.66 (0.48, 0.91) | 0.69 (0.51, 0.93) |
| Meta-regression (RE) | 0.58 (0.26, 1.26) | 0.48 (0.23, 1.01) | 1.03 (0.65, 1.63) | 0.65 (0.46, 0.93) | 0.68 (0.48, 0.95) |
| Daniels & Hughes | 0.58 (0.26, 1.30) | 0.49 (0.23, 1.05) | 1.04 (0.64, 1.69) | 0.64(0.42, 0.99) | 0.67 (0.45, 1.00) |
| BRMA (Wishart) | 0.64 (0.23, 1.75) | 0.60 (0.22, 1.58) | 0.92 (0.43, 1.97) | 0.59 (0.28, 1.22) | 0.71 (0.30, 1.67) |
| BRMA (PNF) | 0.63 (0.28, 1.41) | 0.55 (0.25, 1.21) | 0.97 (0.59, 1.59) | 0.68 (0.45, 1.04) | 0.69 (0.46, 1.05) |
|
|
Havrdova (1) | Havrdova (2) | Sorensen | O'Connor (1) | O'Connor (2) |
| Observed | 1.23 (0.58, 2.62) | 1.04 (0.48, 2.27) | 0.64 (0.32, 1.28) | 1.05 (0.84, 1.31) | 1.10 (0.88, 1.37) |
| Meta-regression (FE) | 0.96 (0.45, 2.05) | 0.86 (0.39, 1.88) | 0.63 (0.31, 1.27) | 1.06 (0.83, 1.37) | 1.00 (0.78, 1.27) |
| Meta-regression (RE) | 0.96 (0.44, 2.07) | 0.86 (0.39, 1.89) | 0.62 (0.30, 1.27) | 1.07 (0.78, 1.45) | 1.00 (0.75, 1.34) |
| Daniels & Hughes | 0.96 (0.43, 2.10) | 0.86 (0.38, 1.92) | 0.62 (0.29, 1.31) | 1.06 (0.79, 1.42) | 0.99 (0.75, 1.32) |
| BRMA (Wishart) | 0.93 (0.34, 2.51) | 0.81 (0.30, 2.19) | 0.63 (0.24, 1.65) | 0.84 (0.43, 1.65) | 0.95 (0.48, 1.87) |
| BRMA (PNF) | 0.93 (0.42, 2.07) | 0.84 (0.37, 1.92) | 0.66 (0.31, 1.42) | 1.01 (0.70, 1.47) | 0.98 (0.68, 1.39) |