Table 1. Inhibitory Profile of Compounds 2a–i against hCA I, II, IV, and VII^a.

		Ki (nM)
compd	(Het)Ar	hCA I	hCA II	hCA IV	hCA VII
2a	Ph	466.1	376.5	3912.1	6.8
2b	4-ClC6H4	453.0	182.1	608.2	0.96
2c	4-FC6H4	428.7	742.2	1036.5	9.4
2d	4-MeOC6H4	317.9	53.3	3643.4	0.97
2e	2-MeC6H4	70.7	61.7	961.2	0.93
2f	2-EtOC6H4	216.3	866.5	2299.7	0.84
2g	3,4-(MeO)2C6H4	847.6	723.6	8302.6	0.87
2h	3-pyridyl	316.0	848.3	1826.6	0.84
2i	5-pyrimidinyl	274.5	703.2	2296.0	0.83
1a	4-FC6H4	2343.0	76.1	9726.0	303.5
1b	4-ClC6H4	960.5	46.7	8142.0	269.0
AAZ		250.0	12.1	74.0	6.0

^aMean K_i values from three different stopped-flow assays (errors were in the range of ±5–10% of the reported values). Inhibitory profile of compounds 1a–b²³ is provided for comparison.