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. 2017 Sep 7;8(10):1093–1098. doi: 10.1021/acsmedchemlett.7b00296

Scheme 2. Synthesis of Compounds 8g and 8h.

Scheme 2

Reagents and conditions: (a) 2-pyridinecarbonyl chloride hydrochloride, DIPEA, DCM; (b) boronic acid, Pd(dppf)Cl2, Na2CO3, 1,4-dioxane, H2O. See Table 1 for the range of substituents.