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. 2017 Sep 22;8(10):1019–1024. doi: 10.1021/acsmedchemlett.7b00196

Table 1. 6-Substituted Quinoline Analogues of Bedaquiline.

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a

clogP calculated by ChemDraw Ultra v13.0 (CambridgeSoft).

b

MIC90 (mg/mL); minimum inhibitory concentration for 90% inhibition of growth of M.tb strain H37Rv, determined under aerobic (MABA)20 conditions. Each value is the mean of at least two independent determinations.

c

IC50 (μM).

d

Data for R,S enantiomer.