. 2017 Sep 29;8(10):1060–1065. doi: 10.1021/acsmedchemlett.7b00269

Table 2. . Cell-Based Readthrough Activity of Esters 13a–e.

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compound	R₄	yield (%)^a	readthrough activity^b	ClogP^c
3 (TCP-126)	n.a^d	n.a^d	2.58 ± 0.07	–1.97
13a	H	16	8.92 ± 0.19	0.02
13b (TCP-199)	o-Br	28	8.84 ± 0.07	0.85
13c	m-Cl	13	5.37 ± 0.22	0.58
13d	o-NO₂	45	9.15 ± 0.21	–0.23
13e	m-OMe	13	5.15 ± 0.13	–0.10

Yields were calculated from intermediate 11 for ester derivatives 13a–e.

Cell-based readthrough activity (ratio) relative to control (D-MEM) in COS-7 cells; compounds are evaluated at a concentration of 200 μM. Values are expressed as the mean ± SD (n = 3).

Value of the calculated log P (ClogP) determined by ChemDraw professional 16.0.

N.a: not applicable.