Table 2. Initial SAR of Diacyl Moieties: All Compounds Are (S)-Enantiomers.

^aIC₅₀ is presented as the mean of duplicate experiments along with 95% confidence intervals (95% CI) in parentheses.

^bSolubility in pH 6.8.

^cMetabolic stability in mice microsomes.

^dMale ICR mice (n = 3). Dose: i.v. at 0.1 mg/kg; p.o. at 1 mg/kg.

^eArea under the curve from 0 to 8 h.

^fBioavailability.