. 2017 Sep 8;8(10):1077–1082. doi: 10.1021/acsmedchemlett.7b00283

Table 3. Representative Compounds in Parallel Synthesis for 3-Phenylpyridin-2(1H)-one Derivatives.

	R	eIF4A3 IC₅₀ (μM)^a		R	eIF4A3 IC₅₀ (μM)^a
1h	2-Cl	0.42 (0.33–0.53)	1k	3-CN	0.19 (0.12–0.29)
1i	3-Cl	0.29 (0.25–0.34)	1l	3-CF₃	0.7 (0.5–0.9)
1j	4-Cl	1.1 (0.8–1.5)	1m	3-SO₂Me	0.49 (0.35–0.69)

IC₅₀ is presented as the mean of duplicate experiments along with 95% confidence intervals (95% CI) in parentheses.