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. 2017 Oct 11;8:1275. doi: 10.3389/fimmu.2017.01275

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Copyright © 2017 Gimenez, Lima, Françoso, Denapoli, Panatieri, Bargieri, Thiberge, Andolina, Nosten, Renia, Nussenzweig, Nussenzweig, Amino, Rodrigues and Soares.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Specific antibody response in mice immunized with Plasmodium vivax circumsporozoite protein (PvCSP) recombinants. (A) C57BL/6 mice were immunized s.c. with three doses 28 days apart with the purified proteins in the presence of the adjuvant Poly(I:C), whereby the antibody response was analyzed according to the timeline described. (B) The IgG antibody serum titers against recombinant proteins representing each allelic form of PvCSP were analyzed by ELISA. The results are expressed as the means ± SD (n = 6). Mouse groups were immunized with: (1) Poly(I:C); (2) Poly(I:C) plus yPvCSP-VK210 (1 μg/dose/mouse); (3) Poly(I:C) plus yPvCSP-VK247 (1 μg/dose/mouse); (4) Poly(I:C) plus yPvCSP-P. vivax-like (1 μg/dose/mouse); (5) Poly(I:C) plus a protein mix [yPvCSP-VK210 (1 μg/dose/mouse) + yPvCSP-VK247 (1 μg/dose/mouse) + yPvCSP-P. vivax-like (1 μg/dose/mouse)]; or (6) Poly(I:C) plus yPvCSP-All epitopes (3 μg/dose/mouse). (C) IgG isotypes were determined by ELISA in sera of mice from groups 5 and 6 described above. Asterisk denotes statistical differences (P < 0.01) when comparing IgG1 isotype with IgG2b, IgG2c and IgG3.