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. 2017 Oct 11;8:1275. doi: 10.3389/fimmu.2017.01275

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Copyright © 2017 Gimenez, Lima, Françoso, Denapoli, Panatieri, Bargieri, Thiberge, Andolina, Nosten, Renia, Nussenzweig, Nussenzweig, Amino, Rodrigues and Soares.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Interferon gamma (IFN-γ)-producing cells in mice immunized with recombinant proteins. (A) C57BL/6 mice were immunized following the scheme with yPvCSP-All epitopes (3 μg/mouse) or a mix of yPvCSP-VK210 + yPvCSP-VK247 + yPvCSP-P. vivax-like (1 μg/each protein/mouse), in the presence of the adjuvant Poly(I:C). (B) To measure the number of cells secreting IFN-γ, splenocytes collected from immunized C57BL/6 mice on day 40 after priming were used for enzyme-linked immunospot (ELISPOT) assays. The recombinant proteins yPvCSP-VK210 (yVK210), yPvCSP-VK247 (yVK247), yPvCSP-P. vivax-like (yVL), and yPvCS-All epitopes (yAll epitopes) were used as stimuli (10 µg/mL). SFC, spot forming cells. Asterisk denotes statistical differences (P < 0.05).