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. 2017 Oct 11;8:1275. doi: 10.3389/fimmu.2017.01275

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Copyright © 2017 Gimenez, Lima, Françoso, Denapoli, Panatieri, Bargieri, Thiberge, Andolina, Nosten, Renia, Nussenzweig, Nussenzweig, Amino, Rodrigues and Soares.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Protection against experimental challenge in mice immunized with a prime-boost regimen. (A) C57BL/6 mice were immunized i.p. with Poly(I:C) or a mixture of Poly(I:C) plus 5 µg of yPvCSP-All epitopes following the scheme described. On day 67 after priming, mice were challenged with 4,000 Pb/PvVK210 transgenic sporozoites. (B) Parasitemia was analyzed by Giemsa-stained blood smears on the following 10 days. Percentage of non-infected mice in each experimental group are shown. (C) Log of parasitemia at day 5 (D5) postchallenge measured in mice immunized with Poly(I:C) (n = 4) or a mixture of Poly(I:C) plus 5 µg of yPvCSP-All epitopes (n = 6). (**) P = 0.0095. (D) The liver load was evaluated by RT-PCR. The infection level in liver in mice immunized with a mixture of Poly(I:C) plus 5 µg of yPvCSP-All epitopes (n = 5) is compared with control group that received Poly(I:C) alone (n = 4). (*) P = 0.0159. C-terminal (CT) differences (delta CT) between the mouse HPRT and Pb 18S CT values are shown.