Fig. 6. Effects of glycopolymers on cytokine secretion by activated DCs. Cells were incubated with GPs before activation with LPS and IFN-γ and multiplex cytokine assay. IL-10 secretion was significantly increased in DC cultures from 4 donors incubated with 8-arm star P3 and 5-arm star P2 GPs at 10 μg ml^–1 compared with controls, but not with linear GP P1 (Panel A). IL-12p70 secretion was significantly decreased compared to controls in cells exposed to increasing concentrations of linear GP P1 (Panel B), 5-arm star GP P2 (Panel C) and 8-arm star GP P3 (Panel D) (all P values calculated from paired t-tests).