Figure 1.

Tolerance to oxycodone, developed using a single-day injection paradigm, was significantly reversed by 0.5 mg/kg diazepam (n = 10 – 20). Latency to tail withdrawal (% MPE ± SEM) among mice that were drug naïve, repeatedly treated with oxycodone, or repeatedly treated with oxycodone and diazepam pretreatment 30 minutes before testing. Various doses of the oxycodone were used for construction of dose-response curves for calculation of ED50 values.