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2 mg/kg Diazepam fully reversed the antinociception produced by hydrocodone in the tail immersion test (n = 6 – 12). Latency to tail withdrawal (% MPE ± SEM) among mice that were drug naïve, repeatedly treated with hydrocodone, or repeatedly treated with hydrocodone and pretreated with diazepam 30 minutes before testing. Various doses of the hydrocodone were used for construction of dose-response curves for calculation of ED50 values.
