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0.5 mg/kg Diazepam fully reversed the antinociception produced by multiple-day paradigm of oral oxycodone in the tail immersion test. (n = 6 – 7). Latency to tail withdrawal (% MPE ± SEM) among mice that were drug naïve, repeatedly gavaged with oxycodone over 4 days, or repeatedly gavaged with oxycodone over 4 days and pretreated with diazepam 30 minutes before testing. Various doses of the oxycodone were used for construction of dose-response curves for calculation of ED50 values.
