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Locomotor stimulation in response to vehicle or oxycodone (64 mg/kg p.o.) was assessed (n = 5). * indicates a significant effect of acute oxycodone increasing ambulatory counts as compared to mice naïve to the opioid (treated with vehicle). † indicates a significant effect of chronic oxycodone + 0.5 mg/kg diazepam increasing ambulatory counts as compared to mice naïve to the opioid (p < 0.05).
