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Locomotor stimulation in response to vehicle, diazepam (0.5 mg/kg i.p.) or oxycodone (64 mg/kg p.o.) was assessed (n = 5). * indicates a significant effect of both acute oxycodone and acute oxycodone + 0.5 mg/kg diazepam increasing ambulatory counts as compared to mice naïve to the opioid (p < 0.05). 0.5 mg/kg diazepam does not potentiate acute oxycodone’s stimulatory effects. 0.5 mg/kg diazepam does not produce a difference in stimulatory counts when compared to naïve controls.
