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Diazepam Reversal of Oxycodone Tolerance
| Treatment | Oxycodone ED50 (mg/kg (95% C.L.)) |
|---|---|
| Acute Oxycodone + Vehicle | 1.19 (1.00–1.41) |
| Acute Oxycodone + Diazepam (0.5 mg/kg) | 1.25 (1.04–1.50) |
| Chronic Oxycodone + Vehicle | 1.84 (1.58–2.14)* |
| Chronic Oxycodone + Diazepam (0.5 mg/kg) | 1.12 (0.88–1.43) |
Significantly different than Acute Oxycodone + Vehicle group based on non-overlapping 95%
