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Diazepam Reversal of Hydrocodone Tolerance
| Treatment | Hydrocodone ED50 (mg/kg (95% C.L.)) |
|---|---|
| Acute Hydrocodone + Vehicle | 5.51 (4.97–6.12) |
| Acute Hydrocodone + Diazepam (2 mg/kg) | 4.48 (3.22–6.25) |
| Chronic Hydrocodone + Vehicle | 13.18 (11.00–15.80)* |
| Chronic Hydrocodone + Diazepam (0.5 mg/kg) | 9.92 (7.74–12.70)* |
| Chronic Hydrocodone + Diazepam (2 mg/kg) | 3.77 (2.83–5.04) |
Significantly different than Acute Hydrocodone + Vehicle group based on non-overlapping 95%
