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. 2017 Oct 16;136(16):1495–1508. doi: 10.1161/CIRCULATIONAHA.117.028084

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© 2017 The Authors.

Circulation is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.

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Figure 1. — Depiction of cardiac troponin and cardiac myosin-binding protein C release during myocardial injury. Structure of cardiac myosin-binding protein C and cardiac troponins in (A) healthy cardiomyocytes and (B) ischemia-induced cardiomyocyte damage. The highlighted N-terminal domain C0C1 is the binding site for the previously developed monoclonal antibodies used for detection of the cardiac-specific isoform of cMyC.¹⁶ cMyC indicates cardiac myosin-binding protein C; cTnI, cardiac troponin I; and cTnT, cardiac troponin T.