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. 2017 Aug 1;158(11):2222–2232. doi: 10.1097/j.pain.0000000000001027

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Copyright © 2017 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The International Association for the Study of Pain.

This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Effect of intraperiaqueductal grey (PAG) and rostroventral medulla (RVM) microinjection of HU210 (CB1/2 receptor agonist, 4 μg/animal) on withdrawal reflexes to mechanical von Frey hair stimulation in P10, P21, and P40 rats. (A) Intra-PAG HU210 significantly decreased spinal reflex excitability compared with vehicle responses in all ages tested (P < 0.0001; 2-way analysis of variance [ANOVA]). This effect was more pronounced in P10 animals compared with P40s. (B) Intra-PAG HU210 significantly increased mechanical thresholds in P21 and P40 rats (P < 0.0001; 2-way ANOVA). This effect is more pronounced in P21 and P40 animals compared with P10. (C) Intra-RVM HU210 decreased spinal reflex excitabilities compared with vehicle responses in all ages tested (P < 0.0001, 2-way ANOVA). This effect was strongest in P21 animals. (D) Intra-RVM HU210 significantly increased mechanical thresholds compared with vehicle responses in all ages tested (P < 0.0001, 2-way ANOVA). This effect was strongest for P21 animals. Four to 8 animals per drug per age group. Data shown here represent the mean ± SEM. **** = P < 0.0001, between drug comparisons, 2-way ANOVA with Bonferroni multiple comparisons. # and #### = P < 0.05 and P < 0.0001, respectively, between age comparison, 2-way ANOVA with Bonferroni multiple comparisons.