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. 2017 Feb 8;2:3. doi: 10.1038/s41525-016-0001-4

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© The Author(s) 2017

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Fig. 1 — Overview of cohorts and differential expression analyses. Monocytes were derived from three subject groups: healthy controls, CD patients with WT NOD2 genotypes (CD_WT), and CD patients with loss-of-function NOD2 genotypes (CD_NOD2). Monocytes were analyzed by RNA-Seq and small RNA-Seq (black body outlines, number of tested individuals is indicated), and selected genes and miRNAs were validated by qPCR in a validation cohort (blue body outlines, number of tested individuals is indicated). We analyzed the difference between subject groups, before and after MDP stimulation (green and yellow arrows, shown in Figs. 2,3), and the response to MDP stimulation within each group (red arrows, shown in Fig. 4)