Figure 1. Lipid accumulation is involved in osteoarthritis pathogenesis.

A. Chondrocytes isolated from either healthy (non-osteoarthritis), or osteoarthritis cartilage from patients who underwent total knee replacement surgery and had different BMIs, were stained with BODIPY. B. Chondrocytes (normal, non-osteoarthritis, and osteoarthritis) were isolated, and total lipid content was analyzed using gas chromatography/mass spectrometry. Lipids were then separated into VLCFA, and either long or medium chain fatty acids (LCFA and MCFA, respectively). The data shown are representative of independent data from at least four patients.