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. 2017 May 19;8(41):69559–69576. doi: 10.18632/oncotarget.18012

Figure 5. HCaRG fosters CpG island hyper-methylation of EGFR and ErbB3 promoters.

Figure 5

Methylation level of CpG island located in EGFR and ErbB3 promoters was quantified using MassARRAY quantitative methylation analysis in Renca clones. Both EGFR and ErbB3 promoters showed significantly higher methylation levels in HCaRG-Renca cells than in Neo-Renca cells. Several hyper-methylated CpG sites located in EGFR and ErbB3 promoters in HCaRG-Renca cells were de-methylated 72 hours after treatment of 5-Aza-CdR. ‡P < 0.05, *P < 0.01, †P < 0.005.