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. 2017 Jul 25;8(41):70035–70048. doi: 10.18632/oncotarget.19550

Figure 5. TMEM176A inhibits tumor growth in esophageal cancer cell xenograft mice.

Figure 5

(A) Representative nude mice burdened with TMEM176A unexpressed and re-expressed KYSE410 cells, the tumor location is shown by black arrowhead. (B) Results of TMEM176A restoration of TMEM176A unexpressed and re-expressed KYSE410 cells, xenografts in mice – Bottom: TMEM176A restoration of TMEM176A expression cells group; Top: control group. (C) The volumes of xenograft tumors in TMEM176A unexpressed and re-expressed KYSE410 cells after inoculation for four weeks. ***p<0.01. (D) Tumor weights from nude mice at the 30th day after inoculation with TMEM176A unexpressed and re-expressed KYSE410 cells. ***p<0.01. (E) IHC staining reveals the expression levels of TMEM176A, MMP2, MMP9 in TMEM176A unexpressed and re-expressed KYSE410 cell xenografts (200×).