Table 1. The association of TMEM176A methylation and clinical factors in esophageal cancer.

Clinical parameter	NO.	Methylation status		P value*
		Methylated	Unmethylated
		n=178	n=89
Gender
Male	167	112	55	p=0.964
Female	100	66	34
Age
≥60	128	82	46	p=0.462
<60	139	96	43
Differentiation
Poorly	84	66	18	p=0.008**
Middle/high	183	112	71
Tumor stage
I/II	160	111	49	p=0.309
III/IV	107	67	40
Lymph node Metastasis
Positive	177	112	65	p=0.131
Negative	90	66	24
Drinking history
Yes	66	46	20	p=0.652
No	201	132	69
Family history
Yes	113	79	34	p=0.405
No	154	99	55
Smoking history
Yes	103	73	30	p=0.65
No	164	105	59
Tumor size
≥3cm	121	87	34	p=0.128
<3cm	146	91	55

*p values are obtained from chi-square test and the Fisher’s exact test, significant difference, p< 0.05.