Table 2. Univariate and multivariate analysis of clinic pathologic factors for overall survival in 267 patients with esophageal cancer.

Risk factors	OS
	Univariate analysis			Multivariate analysis
	HR	Pa	95%CI	HR	Pa	95%CI
Age	0.839	0.325	0.592-1.189
Gender	0.797	0.198	0.564-1.126
TNM stage	1.062	0.728	0.758-1.486
Tumor differentiation	1.841	0.001**	1.288-2.632	1.894	0.000**	1.345-2.65
Lymph node Metastasis	0.845	0.358	0.589-1.211
TMEM176A methylation	2.250	0.001**	1.383-3.661	2.237	0.000**	1.496-3.345
Drinking history	1.211	0.380	0.789-1.859
Family history	1.233	0.218	0.884-1.721
Smoking history	0.871	0.490	0.590-1.288
Tumor size	0.967	0.840	0.701-1.334

HR: hazard ratio. *p < 0.05. **p < 0.01.