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. 2017 Jul 26;8(41):70192–70203. doi: 10.18632/oncotarget.19599

Figure 2. PTL alters cellular morphology.

Figure 2

(A) The cell area decreased in PTL-treated NCI-H446 and NCI-H460. No significant change was found in A549. (B) The pseudopodium number decreased in PTL-treated NCI-H446 and NCI-H460. No significant change was found in A549. (C and D) No significant change was found in DNA content treated with PTL, but CV of DNA in nucleus increased in NCI-H446 and NCI-H460. No significant change was found in A549. (E) The number of pyknosis decreased in all the three cell lines. (F) The number of giant cells increased in all the three cell lines. (G and H) Confocal images of actin cytoskeleton stained with rhodamine–phalloidin and scanning electron micrographs. Treatment of cancer cells with PTL led to theagglutination of β-actin, contraction of pseudopodia, cell shrinkage, and changes in cell shape (*P ≤ 0.05, **P≤ 0.01).