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. 2017 Jul 26;8(41):70192–70203. doi: 10.18632/oncotarget.19599

Figure 5. Effect of PTL on a mouse xenograft model.

Figure 5

Mice were treated with saline or PTL(8 and 16 mg/kg) for 25 d. (A and B) Changes in the tumor volume of LLC xenografts. PTL reduced the tumor volume. PTL treatment inhibited xenograft growth in a dose-dependent manner. (C) Body weights (g) of animals with LLC xenografts.(D) The median survival time was prolonged in a dose-dependent manner following PTL treatment. (E and F) The rate of necrotic regions of tumor markedly increased in tumor tissues of mice. (G and H) The number of tumors that shifted stoves markedly decreased in lungs of mice with LLC xenografts. Each experiment was performed in triplicate. Results show the means of the three experiments, and the error bars represent standard deviation (*P < 0.05 and **P < 0.01).