Table 1. genotype and allele frequency of single nucleotide polymorphisms (SNPs) on IL-23R.
| SNPs | Genotype/Allele | Cases (n = 468) | Controls (n = 480) | P-value | OR (95% CI) |
|---|---|---|---|---|---|
| rs6693831 | CC | 150 (32.1) | 230 (47.9) | 1 | |
| CT | 169 (36.1) | 162 (33.8) | 8.57E-08 | 0.625 (0.464–0.842) | |
| TT | 149 (31.8) | 88 (18.3) | 0.385 (0.276–0.538) | ||
| C | 269 (50.1) | 622 (64.8) | 3.21E-31 | 1 | |
| T | 467 (49.9) | 338 (35.2) | 0.313 (0.256–0.382) | ||
| rs7517847 | TT | 155 (33.1) | 154 (32.1) | 1 | |
| GT | 215 (45.9) | 206 (42.9) | 0.332 | 0.964 (0.719–1.294) | |
| GG | 98 (20.9) | 120 (25.0) | 1.232 (0.870–1.745) | ||
| T | 525 (56.1) | 514 (53.5) | 0.268 | 1 | |
| G | 411 (43.9) | 446 (45.6) | 1.108 (0.925–1.328) | ||
| rs1884444 | TT | 117 (25.0) | 201 (41.9) | 1 | |
| GT | 225 (48.1) | 241 (50.2) | 4.55E-06 | 0.623 (0.466–0.834) | |
| GG | 66 (14.1) | 38 (7.9) | 0.335 (0.212–0.531) | ||
| T | 579 (61.9) | 643 (67.0) | 0.02 | ||
| G | 357 (38.1) | 317 (33.0) | 0.800 (0.662–0.965) | ||
| rs10889677 | AA | 259 (55.3) | 280 (58.3) | 1 | |
| AC | 172 (36.6) | 161 (33.5) | 0.582 | 0.866 (0.659–1.138) | |
| CC | 37 (8.1) | 39 (8.2) | 0.975 (0.603–1.576) | ||
| A | 690 (73.7) | 720 (75.1) | 0.528 | 1 | |
| C | 246 (26.3) | 240 (24.9) | 0.935 (0.761–1.149) |
Abbreviation: OR, odds ratio; CI, confidence interval.
Significant p-values (< 0.05) are highlighted in bold.