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. 2017 Jul 29;8(41):70317–70331. doi: 10.18632/oncotarget.19688

Figure 2. TriVax or BiVax/IL2Cx generate vast T cell responses in RIP-gp mice.

Figure 2

(A, B) RIP-gp mice were vaccinated with pam-gp33-41 BiVax and 14 days later they were boosted with TriVax or BiVax/IL2Cx. Percentage of Kb (A) and Db (B) tetramer+ CD8 T cells in the blood. (C) Total numbers of Kb and Db specific CD8 T cells in spleens after boost. (D) Splenocytes were stimulated in vitro with the minimal gp33-41 peptide in the presence of Golgiplug for 6 h and the production of IFNγ, TNFα, IFNγ/TNFα, IL-2 and granzyme B was assessed by intracellular staining. Results are presented for individual mice (each symbol) with the mean ± SD for each group. (ns: not significant).