Figure 1. The expression of TMEM17 in NSCLC specimens.

(A and B). TMEM17 was positively expressed in noncancerous tissues samples and only showed weak or negative expression in paired NSCLC samples. TMEM17 expression is significantly higher in normal lung tissue than that in NSCLC samples (P=0.010). (C, scale bar = 50 μm, insert scal bar=20μm) Representative images of IHC staining in cases 2, 10 and 11, TMEM17 showed cytosolic expression in all the cases. The expression of TMEM17 in HBE cells was higher than most of the NSCLC cell lines (except A549; D), and localized in the cytoplasm of HBE and A549 cells (E, left). Overexpressed TMEM17 is localized primarily in the cytoplasm in H1299 cells (detected by myc-tag, right). No positive signal is detected in non-transfected cells, 600× magnification