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. 2017 Aug 7;8(41):70736–70751. doi: 10.18632/oncotarget.19982

Figure 3. The effect of dasatinib on AKT and ERK signaling in HCC827 cells and its drug-resistant sublines.

Figure 3

(A) The expression of SFK family proteins and activation of SFKs. (B) The inhibitory effects of dasatinib on cell survival of HCC827, BR1-8, and BR2-3 cells. Each value represents the average of triplicate dishes for each cell line. *P < 0.05. (C) Western blot analysis of the inhibitory effects of incubating cells with dasatinib (100 nmol/L) for 6, 12, and 24 h. The quantification of the western blots is shown, and the values were normalized to those of β-actin.