Table 4. Treatment-related toxicities.
| Toxicities | Combined group | Control group | P value | |||
|---|---|---|---|---|---|---|
| All grades N (%) | Grade 3/4 N (%) | All grades N (%) | Grade 3/4 N (%) | All grades | Grade3/4 | |
| Hematologic | ||||||
| Leukopenia | 7 (58.3) | 1 (8.3) | 18 (85.7) | 3 (14.3) | 0.07 | 0.61 |
| Neutropenia | 7 (58.3) | 1 (8.3) | 18 (85.7) | 3 (14.3) | 0.07 | 0.61 |
| Anemia | 10 (83.3) | 0 | 17 (80.9) | 1 (4.8) | 0.67 | 0.44 |
| Thrombocytopenia | 4 (33.3) | 0 | 4 (19.1) | 1 (4.8) | 0.35 | 0.44 |
| Non-hematologic | ||||||
| Asthenia | 7 (58.3) | 0 | 16 (76.2) | 1 (4.8) | 0.28 | 0.44 |
| Anorexia | 7 (58.3) | 0 | 16 (76.2) | 1 (4.8) | 0.28 | 0.44 |
| Allergy | 1 (8.3) | 0 | 3 (14.3) | 0 | 0.61 | |
| Nausea | 8 (66.7) | 1 (8.3) | 12 (57.1) | 2 (9.5) | 0.59 | 0.91 |
| Vomiting | 8 (66.7) | 1 (8.3) | 12 (57.1) | 2 (9.5) | 0.59 | 0.91 |
| Diarrhea | 2 (16.7) | 0 | 3 (14.3) | 0 | 0.85 | |
| Constipation | 7 (58.3) | 1 (8.3) | 15 (71.4) | 1 (4.8) | 0.44 | 0.67 |
| Stomatitis | 2 (16.7) | 0 | 2 (9.5) | 0 | 0.54 | |
| Hyperbilirubinemia | 2 (16.7) | 0 | 7 (33.3) | 1 (4.8) | 0.30 | 0.44 |
| Elevated AST/ALT | 8 (66.7) | 0 | 7 (33.3) | 1 (4.8) | 0.06 | 0.44 |
| Peripheral neuropathy | 7 (58.3) | 0 | 10 (47.6) | 0 | 0.55 | |
| Hand-foot syndrome | 5 (41.7) | 0 | 6 (28.6) | 1 (4.8) | 0.44 | 0.44 |
| Hypertension | 3 (25.0) | 0 | 1 (4.8) | 0 | 0.09 | |
| Bleeding | 1 (8.3) | 0 | 0 | 0 | 0.18 | |
AST, aspartate aminotransferase; ALT, alanine aminotransferase.