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. 2017 Aug 10;8(41):70916–70940. doi: 10.18632/oncotarget.20200

Figure 5. CADD522 inhibits transcription of RUNX2 responsive genes.

Figure 5

(A) Q-RT-PCR analyses of MMP13, VEGF, and MMP9 were performed in ectopic RUNX2-expressing T47D and MCF7 cells. Cells were treated CADD522 (50 μM) for 72 hrs. *, P<0.05 compared to Empty controls with vehicle alone (-); #, P<0.05 compared to RUNX2-expressing cells with vehicle control. (B) Q-RT-PCR analyses of RUNX2 target genes in MDA-231 cells. Cells were treated with CADD522 (50 μM) for 6 hrs. Similar results were observed in cells treated with CADD522 for 24 hrs (data not shown). *, P<0.05 compared to vehicle control (0.1% DMSO).