Table 2. Indirect miR-708-5p targets.
| Name of Target | Cancer | Regulates Expression | Role in Cancer | Reference |
|---|---|---|---|---|
| TNF-α | CLL | down | Inflammation | 33 |
| CXCL1 | CLL | down | Inflammation | 33 |
| NFKBIA | CLL | down | Inflammation | 33 |
| AKT-1 | GBM | Down | PI3K signaling | 137 |
| Cyclin D1 | GBM | Down | Cell cycle progression | 137 |
| MMP-2 | GBM, Lung | Down | promotes invasion | 137, 193 |
| EZH2 | GBM | Down | proliferation, DNA Repair | 137 |
| BCL-2 | GBM | Down | Anti-apoptotic | 137 |
| PARP-1 | GBM | Down | Proliferation, DNA Repair | 137 |
| E-cadherin | RCC | Up | inhibits invasion | 175 |
| MCAM | RCC | Down | EMT, invasion | 175 |
| Fibronectin 1 | RCC | Down | EMT, invasion | 175 |
| TRAIL | RCC | Up | Pro-apoptotic signaling | 175 |
| TMEM88 | Lung | down | Negative regulator of WNT signaling | 192 |
| BCL2A1 | Lung | down | Anti-apoptotic | 193 |
| BCL2L2 | Lung | down | Anti-apoptotic | 193 |
| PIK3IP1 | Lung | up | Suppresses PI3K signaling | 193 |
| PHLDA3 | Lung | up | Suppresses PI3K signaling | 193 |
| INPPL1 | Lung | up | Suppresses PI3K signaling | 193 |
| MMP-9 | Lung | down | promotes invasion | 193 |
| VEGFC | Lung | down | promotes invasion | 193 |
| CADM1 | Lung | down | promotes invasion | 193 |
| CD117 | Lung | down | cancer stem cell marker | 193 |
| CD34 | Lung | down | cancer stem cell marker | 193 |
| OCT4 | Lung | down | cancer stem cell marker | 193 |
| ALDH1A2 | Lung | down | cancer stem cell marker | 193 |
| NANOG | Lung | down | cancer stem cell marker | 193 |