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. 2017 Aug 2;8(41):71317–71324. doi: 10.18632/oncotarget.19813

Figure 2. PLZF regulatory network in prostate cancer.

Figure 2

Androgen receptor (AR) activation induces PLZF expression, while PLZF acts as a negative feedback regulator of AR. In addition, PLZF represses mTORC1 signaling by upregulating REDD1 expression and RAS/RAF/MEK signaling through increasing related gene expression. PLZF can also prevent the formation of PBX1-HOX heterodimers. Activation of PI3K-AKT pathway inhibits FOXO3 which normally activates PLZF expression. Highly prostate enriched protein KLK4 whose expression is androgen dependent, is a key regulator of PLZF: it physically interacts with and inhibits PLZF inhibited pathways, resulting in tumor growth.