Fig. S6.

Proposed mechanosensitive mechanism of regulation of endothelial morphology. DHH, an integral component of the hedgehog signaling pathway, is up-regulated in PS vs. ST while being down-regulated in both OS vs. ST and OS vs. PS. DHH signaling activates the Gli family of TFs. Among the Gli targets is STMN3, a stathmin protein that is involved in microtubule formation and function. The expression profile of STMN3 exhibits strong similarity with the expression profile of DHH, indicating a potential signal transduction from shear to transcriptional regulation.