Fig. 2.

Possible karyotypes of gametes generated by an RecT or RobT carrier. (A) An RecT carrier may generate gametes with 32 different possible karyotypes. The karyotype of the mother or father in its diploid (somatic) state is shown at the far left. After fertilization with a normal gamete, the 32 resulting zygotic karyotypes may be categorized into three types. Type I gamete karyotypes show balanced ploidy in either an RecT carrier or a normal embryo. These embryos are candidates for MaReCs selection. Type II gamete karyotypes contain 20 abnormal karyotypes, and each of these karyotypes is biunique with its corresponding CNV pattern. These abnormal embryos can be functional and used as the reference for allelic haplotype mapping in MaReCs. Type III gamete karyotypes contain eight abnormal karyotypes corresponding to only four CNV patterns and two abnormal karyotypes with aneuploidy without a breakpoint; thus they cannot be used as reference embryos in MaReCs. (B) Gamete karyotypes from a RobT carrier are not as complex as those of an RecT carrier. The karyotype of mother or father in its diploid (somatic) state is shown at the far left. While the type I gamete also contains two karyotypes (normal and RobT), the type II gamete includes only four abnormal karyotypes, and the type III gamete includes two abnormal karyotypes.