Figure 7. Schematic representation of the “anchoring” of the growth factor into alginate sulfate (A) and summary of sequential delivery of growth factors from alginate in vivo (B).

The faster release of insulin-like growth factor 1 (IGF-1) could provide strong pro-survival signals at early stages, while the slower release of HGF could induce angiogenesis at later stages. Reprinted with permission from [75] and from [32].