4. Changes in results over time.

	Trend or interaction 1998	Trend or interaction 2005	Trend or interaction 2010 'old' methods	Trend or interaction 2010 'new' methods and TNM changes
Age	P = 0.34	P = 0.44	P = 0.32	P = 0.20
Sex	P = 0.94	P = 0.92	P = 0.84	P = 0.49
Histology	P = 0.75	P = 0.61	P = 0.42	P = 0.38
Stage	P = 0.0003	P = 0.003	P = 0.003	P = 0.12
Nodal status	P = 0.016	P = 0.02	P = 0.03	P = 0.39