Belgium 1966.
Methods | 1966 to 1977 RCT |
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Participants | 224 patients
Stages I, II, III Trial data used in subgroup analyses for sex, age and histology |
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Interventions | Surgery + radiotherapy vs surgery alone RT details 60 Gy in 30 fractions in 6 weeks Prescription technique: isodose 90% Machine used: Co60 Average field size (cm): 15 × 9 Clinical target volume: bronchial stump, hilum, mediastinum Technique: spinal cord blocks, oblique fields, lateral fields | |
Outcomes | Survival | |
Notes | 20 small cell participants excluded from meta‐analysis Unable to supply data for 2 participants | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Low risk | Comment: stated as randomised in paper; checks run on IPD suggest adequate sequence generation |
Allocation concealment (selection bias) | Low risk | Quote: "randomisation carried out via sealed envelope" |
Blinding (performance bias and detection bias) All outcomes | Low risk | Comment: trial not blinded owing to the nature of the intervention; outcome not likely to be influenced by lack of blinding |
Incomplete outcome data (attrition bias) All outcomes | Low risk | Comment: individual participant data obtained and checked for all outcomes |
Selective reporting (reporting bias) | Low risk | Comment: individual participant data obtained and checked for all outcomes |
Other bias | Low risk | Comment: study apparently free of other sources of bias |