Lille 1985.

Methods	1985 to 1991 RCT
Participants	163 patients Stage I Trial data used in subgroup analyses for sex, age, histology, stage and nodal status
Interventions	Surgery + radiotherapy vs surgery alone RT details 45 to 60 Gy in 22.5 to 30 fractions in 6 weeks Prescription technique: isodose 90% Machine used: Co60 and linac Average field size (cm): 12 × 12 Clinical target volume: hilum, upper mediastinum Technique: spinal cord blocks, oblique fields, lateral fields
Outcomes	Survival
Notes	—
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Quote: "randomised with a table of randomisation according to Snedecor and Cochran" Comment: stated as randomised in paper; checks run on IPD suggest adequate sequence generation
Allocation concealment (selection bias)	Low risk	Quote: "randomised with a table of randomisation according to Snedecor and Cochran"; insufficient information provided
Blinding (performance bias and detection bias) All outcomes	Low risk	Comment: trial not blinded owing to the nature of the intervention; outcome not likely to be influenced by lack of blinding
Incomplete outcome data (attrition bias) All outcomes	Low risk	Comment: individual participant data obtained and checked for all outcomes
Selective reporting (reporting bias)	Low risk	Comment: individual participant data obtained and checked for all outcomes
Other bias	Low risk	Comment: study apparently free of other sources of bias