MRC LU11.
Methods | 1986 to 1993 RCT |
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Participants | 308 patients
Stages II, III Trial data used in subgroup analyses for sex, age, histology, stage and nodal status |
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Interventions | Surgery + radiotherapy vs surgery alone RT details 40 Gy in 15 fractions in 3 weeks Prescription technique: central axis, at midplane Machine used: Co60 and linac Average field size (cm): unavailable Clinical target volume: hilum, mediastinum, supraclavicular fossae for upper lobes Technique: spinal cord blocks, oblique fields, lateral fields | |
Outcomes | Survival | |
Notes | — | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Low risk | Comment: stated as randomised in paper; checks run on IPD suggest adequate sequence generation |
Allocation concealment (selection bias) | Low risk | Quote: "treatment assigned by central office" |
Blinding (performance bias and detection bias) All outcomes | Low risk | Comment: trial not blinded owing to the nature of the intervention; outcome not likely influenced by lack of blinding |
Incomplete outcome data (attrition bias) All outcomes | Low risk | Comment: individual participant data obtained and checked for all outcomes |
Selective reporting (reporting bias) | Low risk | Comment: individual participant data obtained and checked for all outcomes |
Other bias | Low risk | Comment: study apparently free of other sources of bias |