MRC LU11.

Methods	1986 to 1993 RCT
Participants	308 patients Stages II, III Trial data used in subgroup analyses for sex, age, histology, stage and nodal status
Interventions	Surgery + radiotherapy vs surgery alone RT details 40 Gy in 15 fractions in 3 weeks Prescription technique: central axis, at midplane Machine used: Co60 and linac Average field size (cm): unavailable Clinical target volume: hilum, mediastinum, supraclavicular fossae for upper lobes Technique: spinal cord blocks, oblique fields, lateral fields
Outcomes	Survival
Notes	—
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Comment: stated as randomised in paper; checks run on IPD suggest adequate sequence generation
Allocation concealment (selection bias)	Low risk	Quote: "treatment assigned by central office"
Blinding (performance bias and detection bias) All outcomes	Low risk	Comment: trial not blinded owing to the nature of the intervention; outcome not likely influenced by lack of blinding
Incomplete outcome data (attrition bias) All outcomes	Low risk	Comment: individual participant data obtained and checked for all outcomes
Selective reporting (reporting bias)	Low risk	Comment: individual participant data obtained and checked for all outcomes
Other bias	Low risk	Comment: study apparently free of other sources of bias