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. 2016 Oct 11;2016(10):CD002142. doi: 10.1002/14651858.CD002142.pub4

Slovenia 1988.

Methods 1988 to 1992 RCT
Participants 74 patients
 Stage III
Trial data used in subgroup analyses for sex, age, histology, stage and nodal status
Interventions Surgery + radiotherapy vs surgery alone
 RT details
 30 Gy in 10 to 12 fractions in 2 weeks
 Prescription technique: central axis, at the midplane
 Machine used: linac
 Average field size (cm): 9 × 12
 Clinical target volume: hilum, mediastinum
 Technique: oblique fields, lateral fields
Outcomes Survival
Notes Sealed envelope randomisation
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Comment: stated as randomised in paper; checks run on IPD suggest adequate sequence generation
Allocation concealment (selection bias) Low risk Quote: "randomisation carried out via sealed envelope"
Blinding (performance bias and detection bias) 
 All outcomes Low risk Comment: trial not blinded owing to the nature of the intervention; outcome not likely influenced by lack of blinding
Incomplete outcome data (attrition bias) 
 All outcomes Low risk Comment: individual participant data obtained and checked for all outcomes
Selective reporting (reporting bias) Low risk Comment: individual participant data obtained and checked for all outcomes
Other bias Low risk Comment: study apparently free of other sources of bias

All trials supplied individual participant data for analysis and therefore are defined as unpublished data, even though most are published.

IPD = individual participant data.
 RCT = randomised controlled trial.
 RT = radiotherapy.1G