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. 2017 Oct 1;2017:3519158. doi: 10.1155/2017/3519158

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Copyright © 2017 Tien-Huang Chen et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Upregulation of BiP/GRP78 in C6/36 cells with dengue 2 virus (DENV2) infection. (a) The expression of BiP/GRP78 mRNA in C6/36 cells infected with DENV2 was validated by a real-time RT-qPCR, showing that the expression of this gene significantly changed along with the time of infection (p < 0.05; one-way ANOVA). Specifically, it remained unchanged (1.06-fold) at 0 and 6 h postinfection (hpi) but had increased 2.58-fold by 12 hpi and 2.94-fold by 18 hpi and had reached a peak (5.20-fold) by 24 hpi. BiP/GRP78 mRNA levels had subsequently fallen back to 2.67- and 2.76-fold increases at 30 and 36 hpi, respectively. (b) The number of cells infected with DENV2 increased about 2-fold between the initial inoculation (at 0 hpi) and 24 hpi, and a stable level then remained from 36 to 48 hpi. This reveals that the change in BiP/GRP78 was not the effect of cell growth.