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. 2017 Oct 16;12(10):e0186354. doi: 10.1371/journal.pone.0186354

Fig 5. Relationship between the N-terminal capping A1 helix position and the TPR groove content.

Fig 5

(A) Superposition of the unnatural His-tag fusion of KLC1-TPR[A1-B6] (3NF1, orange) and the natural LFP-motif from KLC2-LFPTPR[A1-B6] (5FJY, green). TPR domain superposition is done on the TPR2 motif. Only the KLC1-TPR[A1-B6] structure (3NF1) is shown for clarity in white cartoon surrounded by a transparent surface representation. The “OUT” A1 helix is indicated in dark grey. The Phe202* from the His-tag linker (3NF1, orange) is shown in sticks. (B) The KLC1-TPR[A1-B5] (this study) contacting the B5’-sym helix (pink). KLC1-TPR[A1-B5] is shown in white cartoon surrounded by a transparent surface representation. The “OUT” A1 helix is indicated in dark grey. The Phe416’ from the αB5’-sym (pink) is shown in sticks.