Table 3. Helix crossing measurements for TPR domain closure.
(αA2 - αA5) | TPR | αA2/αA3 | |||
---|---|---|---|---|---|
Fragments | Angle (°) | Dist. (Å) | Conformation | ||
KLC1 | |||||
5OJ8_A | [A1-B5] | 55.0 | 26.8 | CLOSE | Yes |
3NF1_A | [A1-B6] | 49.8 | 29.9 | Intermediate | No |
KLC2 | |||||
5OJF_B | [A1-B6] | 62.9 | 31.5 | OPEN | No |
5FJY_A | LFP-[A1-B6] | 66.2 | 31.3 | OPEN | No |
3CEQ_A | *[B1-A6] | 65.8 | 32.8 | OPEN | No |
3EDT_H | *[B1-A6] | 67.9 | 31.2 | OPEN | No |
3ZFW_A | *[B1-A6] | 54.3 | 28.0 | CLOSE | Yes |
*the A1 helix is absent from the TPR fragment crystallized, thus A1 helix crossing measurements cannot be calculated.