Table 2.

Asthma exacerbation genes identified by gene-environment interaction studies

	Gene	Chromosome Location	SNP(s)	Population(s)	HGVS Name	Reference
1	CDHR3	7q22.3	rs6967330c	Denmark (Caucasians); UKa (Caucasians); Netherlands (Caucasians and non-Caucasians)	NC_000007.14:g.106018005G>A	[41]
2	CRTAM	11q24.1	rs7941607c rs2272094c rs2140151c	USb (Caucasians); Costa Rica	NC_000011.10:g.122867102C>T NC_000011.10:g.122867553A>G NC_000011.10:g.122866145A>C	[50]
3	IL-10	1q31-q32	rs1800896c rs3024492c rs3024496c	US (Caucasians); Costa Rica	NC_000001.10:g.206946897T>C NC_000001.10:g.206944112T>A NC_000001.10:g.206941864A>G	[51]
4	TGFβ1	19q13	rs1800470c rs2241712c	US (Caucasians); Costa Rica	NC_000019.10:g.41354391A>G NC_000019.10:g.41363851C>T	[27]
5	IL-9	5q31.1	rs11741137c rs2069885c	US (Caucasians); Costa Rica US (Caucasians); Costa Rica; Puerto Rico	NC_000005.10:g.135890448C>T NC_000005.10:g.135892476G>A	[52]
6	ADAM33	20p13	rs512625c	Croatia	NC_000020.10:g.3648378A>G	[53]
7	SIGLEC1	20p13	rs532448c	Croatia	NC_000020.10:g.3666838A>T	[53]

^aUnited Kingdom

^bUnited States

^cstudied only in pediatric population(s)